Recognizing that none of Louisville's four existing medical schools would accept Black students, Dr. Fitzbutler took action. In 1888, he secured a charter from the Kentucky Legislature to organize the Louisville National Medical College — a medical school that would accept African Americans.
Serving as Dean, Chair of Surgery, and majority owner, Fitzbutler led the institution with a vision of expanding opportunity and excellence in medical training. The college became the finest African American medical school in the United States — and the only one entirely owned and operated by African Americans.
Alongside the college, Fitzbutler established Louisville Hospital in 1894, housed in two buildings neighboring the school, providing both clinical training for students and direct care to the community. Over its 24-year history, the Louisville National Medical College graduated 175 physicians — many of whom went on to serve communities across the country that otherwise lacked access to care.
When Abraham Flexner conducted his historic 1909 inspection of medical schools, he found the college's hospital to be among the cleanest and best run in the country. Tragically, the curricular reforms mandated in response to the Flexner Report led to the closure of many medical schools — disproportionately those serving minority populations. The Louisville National Medical College closed in 1912.